Effect of Hyperbaric Oxygen Therapy Combined with Golden Sea Cucumber (Stichopus hermanii Powder to the Level Of Blood Glucose Diabetic Wistar Rat Induced Porphyromonas gingivalis

Authors

  • Rafika Rusydia Darojati Sarjana Kedokteran Gigi Fakultas Kedokteran Gigi Universitas Hang Tuah Surabaya
  • Yoifah Rizka Periodonsia Fakultas Kedokteran Gigi Universitas Hang Tuah Surabaya
  • Syamsulina Revianti Biologi Oral Fakultas Kedokteran Gigi Universitas Hang Tuah Surabaya

Keywords:

Diabetes mellitus, periodontitis, blood glucose levels, Stichopus hermanii, hyperbaric oxygen.

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorders characterized by hyperglycemia caused by oxidative stress. Porphyromonas gingivalis (P.g) is a periodontopathogen caused periodontitis exacerbate blood glucose levels (BGL). Hyperbaric oxygen therapy (HBOT) combined with stichopus hermanii (SH) has a role as an antioxidant and antibacterial agent. Purpopse: To analysis effect of HBOT, SH powder and combination of both to the level of blood glucose diabetic Wistar rat induced P.g. Materials and Methods: This study was pre-test-post-test control group design, using 20 male Wistar rat were divided into 5 groups, Group1 (STZ), Group2 (STZ+P.g), Group3 (STZ+P.g+HBOT), Group4 (STZ+P.g+SH powder), Group5 (STZ+P.g+HBO+SH). STZ induction intravenous for 4 days in a row. P.g. induction was exposure 3 times for 4 days. After therapy (7 days), sample blood tail vein of rat were taken for measure BGL by glucometer. Result: Level of blood glucose K1(280.25±88.786)mg/dl, K2(372.25±135.662)mg/dl, K3(249.50±96.652)mg/dl, K4(172.00±82.077)mg/dl, K5(104.75±38.257)mg/dl. Conclusion: Induction of STZ increased the BGL but induction of P.g. cannot exacerbate BGL . HBOT combined with SH powder can reduce BGL in STZ and P.g. induction group.

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Published

2021-08-16

How to Cite

Rafika Rusydia Darojati, Yoifah Rizka, & Syamsulina Revianti. (2021). Effect of Hyperbaric Oxygen Therapy Combined with Golden Sea Cucumber (Stichopus hermanii Powder to the Level Of Blood Glucose Diabetic Wistar Rat Induced Porphyromonas gingivalis. DENTA JURNAL KEDOKTERAN GIGI, 11(2), 18–28. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/90

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Vol. 11 No. 2 (2017): Agustus

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