Effectivity of the Gold Sea Cucumber Supplementation (Stichopus hermanii) of Catalase Activity in Wistar Rat’s Submandibular with Oral Candidiasis

Authors

  • Ajeng Hanun Winny Khairina Sarjana Kedokteran Gigi Fakultas Kedokteran Gigi Universitas Hang Tuah
  • Syamsulina Revianti Departemen Biologi Oral Fakultas Kedokteran Gigi Universitas Hang Tuah
  • Nafi’ah Departemen Ilmu Penyakit Mulut Fakultas Kedokteran Gigi Universitas Hang Tuah

Keywords:

Oral candidiasis, catalase activity, Stichopus hermanii, Candida albicans

Abstract

Background: Oral candidiasis is common opportunistic infection in oral cavity caused by the fungal pathogen Candida albicans and it can develop to malignant such as a candida leukoplakia if it’s affected by cigarette smoke exposure. Purpose: To analysis the effectivity of Stichopus hermanii supplementation of catalase activity in Wistar rats submandibular with oral candidiasis. Materials and Methods: This study was post-test-only control group design, using 35 male Wistar rats were divided into 5 groups, Group1 is negative control,  Group2 is positive control, Group3 is treatment control with Stichopus hermanii 0,0225 mg/g BB powder, Group4 is treatment control with Stichopus hermanii 0,045 mg/g BB powder) Group5 is treatment control with Stichopus hermanii 0,09 mg/kg BB powder). Oral candida infection was achieved by spray and cotton swab rolled over all parts of the mouth. After treatment, rats were euthanized and submandibular were biopsied to make histopathology slide for measure activity of enzim catalase with spectrophotometer λ 280 nm. Data were analyzed using One Way ANOVA and Tukey LSD test. Results: There are significantly differences catalase activity between K1&K2, K2&K3, K4&K1, K2&K4, K2&K5. Conclusion: Suplementation of Stichopus hermanii effectiv of catalase activity in wistar rat’s submandibular with Candida albicans A infection.

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References

Suyoso S. Kandidiasis Mukosa. Departemen/ SMF Ilmu Kesehatan Kulit dan Kelamin. Surabaya: fakultas Kedokteran Universitas Airlangga/ RSUD Dr. Soetomo Surabaya; 2013. h. 1-5

Akpan A, Morgan R. Oral Candidiasis. Postgrad Med J. UK. 2002. p. 455-9

Lamont RJ, Burne RA, Lantz MS, Leblanc DJ. fungi and fungal infections of the oral cavity. Oral microbiology and immunology. 2006. p. 333–348.

Sitheeque and Samaranayake, 2003. Chronic Hyperplatic Candida (Candidal Leukoplakia). Journal of Crit Rev Oral Biol Med.P.253-267.

Hyfywedd FN and Meinwe CG. 2014. Management of Hyperkeratosis of the Lower Limb. All wales tissue viability nurse forum. p.2-3

Chen L, Shujuan G, Matthew JR, Luisa AD. Toll- Like Receptor 4 Plays an Essential Role in Early Skin Wound Healing. Journal Invest Dermatol. 2013. 133(1): 258-67.

Komariah RS. Kolonisasi Candida dalam Rongga Mulut. Majalah kedokteran FK UKI. 2012; XXVIII(1): 46-39.

Lee J, Taneja V, Vassallo R. Cigarette Smoking and Inflamation: Cellular and Molecular Mechanisms. Journal of Dental Research. 2012; 91(2): 149-142.

Halliwell B, Gutteridge J. Free Radical in Biology and Medicine 2nd ed. Oxford: Oxford Science Publicatio; 1999. p. 27-28; 53-56; 105-106; 134-136; 246-248; 301; 585.

Winarsi Hery. Antioksidan Alami dan Radikal Bebas cetakan 1. Yogyakarta: Kanisius (Anggota IKAPI); 2007. p .49-64

Mark H. Post Oxidative Stress. Haworth press. 2000. p. 134-135

Romani, L., and Bistoni, F. Systemic immunity in candidiasis. Fungal pathogenesis: principles and clinical applications; 2002. p. 483– 514

Nakagawa Yoshiyuki , Toshio Kanbe, and Ikuyo Mizuguchi. Disruption of the Human Pathogenic Yeast Candida albicans Catalase Gene Decreases Survival in Mouse-Model Infection and Elevates Susceptibility to Higher Temperature and to Detergents. Microbiol. Immunol., 2003; 47(6): 403-395.

Mojtaba, eizadi, Khorshidi Davood and Dooaly Hussein. Lower Total Antioxidant Capacity in Smokers Compare to Non-smokers. Biological Forum An International Journal. 2014. p. 305-309.

Zainuri, Masagus, Septelia Inawati Wanandi. Efektivitas Spesifik Manganese Superoxide Dismutase (MnSOD) dan katalase pada hati tikus yang diinduksi Hipoksia sistemik : Hubungannya dengan kerusakan oksidatif. Media Litbang Kesehatan. 2012; 22(2): 23-17.

Taguchi Yuuki, Takizawa Toshio, Ishibasi Hiroko, Sagawa Takehito, Arai Ryo, Inoue Shigeharu, Yamaguchi Hideyo, Abe Shigeru. Therapeutic Effects on Murine Oral Candidiasis by Oral Adimistration of Cassia (Cinnamon cassia) Preparation. Jpn. J. Med. Mycol. Japan. 2010;51:21-13. ISSN 0916-4804

Williams David, Lewis Michael. Pathogenesis and Treatment of Oral Candidosis. Journal of Oral Microbiology. 2011. p.17-13.

Dantas, Alessandra da Silva, Alison Day, Mélanie Ike, Iaroslava Kos, Beatrice Achan and Janet Quinn. Oxidative Stress Responses in the Human Fungal Pathogen. 2015.

Bordbar, S., Farooq Anwar, and Nazamid Saari. High-Value Components and Bioactives from Sea Cucumbers for Functional Foods—A Review. 2011. Avalaible from www.mdpi.com/journal/marinedrugs

Maisuthisakul, Pitchaon. Phenolic Constituents and Antioxidant Properties of some Thai Plants. University of the Thai Chamber of Commerce, Thailand. 2017. p. 41-56.

Sulastri delmi, Keswani Ryan. Pengaruh pemberian isoflavon terhadap jumlah eritrosit dan aktivitas enzim katalase yang dipapar sinar UV. Majalah kedokteran andalas.2019. p. 171-178.

Sudibyo. Metodologi Penelitian. Aplikasi Penelitian Bidang Kesehatan cetakan ke 2 ISBN 978-979-028-096-0. Surabaya: Unesa University Press; 2013. p. 129-131.

Silvia FS. Pengukuran Aktivitas spesifik enzim katalase. Jakarta : Universitas Indonesia; 2009 .p.23-32.

Scully Crispian. Oral and Maxillofacial Medicine 3ed. Churchill Livingstone: Elsevier; 2013. p. 254-265.

Gaib Z. Faktor-faktor yang Berpengaruh terhadap terjadinya Kandidiasis Eritematosa pada Pengguna Gigi Tiruan Lengkap. Manado: Proram Studi Kedokteran Gigi Universitas Sam Ratulangi; 2013. p.1-14.

Soysa NS, Ellepola AN. The Impact of Cigarette/Tobacco Smoking On Oral Candidosis: an overview. Oral Diseases. 2005; 11(5): 268-267.

Rad M, Kakoie S, Brojeni FM, Pourdamghan N. Effect of Long Term Smoking on Whole-mouth Salivary Flow Rate and Oral Health. JODDD. 2010; 4(4): 114-110.

Lee J, Taneja V, Vassallo R. Cigarette Smoking and Inflamation: Cellular and Molecular Mechanisms. Journal of Dental Research. 2012: 91(2): 149-142.

Murray Robert K, Granner Daryl K, Mayes Peter A, Rodwell Victor W. Biokimia Harper 25 ed. Jakarta: EGC; 2003. p. 123

Astuti S. Isoflavon Kedelai dan Potensinya sebagai Penangkap Radikal Bebas. Jurnal Teknologi Industri dan Hasil Pertanian. 2008; 13(2): 133-126.

Ridwan Endi. Etika Pemanfaatan Hewan Percobaan Dalam Penelitian. J Indon Med Assoc. 2013; 63: 44-32.

Rukmini A. Regenerasi Minyak Goreng Bekas Dengan Arang Sekam Menekan Kerusakan Organ Tubuh. Seminar Nasional Teknologi. 2007. p. 60.

Suwandi T. Pemberian Ekstrak Kelopak Bunga Rosela Menurunkan Malondialdehid Pada Tikus Yang Diberi Minyak Jelantah [Tesis]. Denpasar: Universitas Udayana; 2012.p. 89-90.

Ingriani N. Pemberian Ekstrak Biji Irvingia gabonensis Mencegah Kenaikan Berat Badan Dan Berat Lemak Abdominal Pada Tikus Jantan Yang Diberi Diet Tinggi Karbohidrat Dan Lemak [Tesis]. Denpasar: Universitas Udayana; 2012.

Revianti Syamsulina. Pengaruh Radikal Bebas pada Rokok Terhadap Timbulnya Kelainan di Rongga Mulut. DENTA Jurnal Kedokteran Gigi FKG-UHT. 2007; 1(2): 89-85.

Abegg MA et al. Response to Oxidative Stress in Eight Pathogenic Yeast Spesies of the Genus Candida. Mycopathologia. 2010; 170: 20-11.

Christianto T, 2000. Radikal Bebas dan Diabetes Mellitus, Pertemuan ilmiah Berkala I Ilmu Penyakit Dalam

Mayes 2003, Struktur dan Fungsi Vitamin larut Lipid dalam biokimia Harper edisi 25 Jakarta, EGC.P.365

Solaleh Emamgholipur, Arash Hossein Nezhad, Mohammad Ansari, 2016. Can Melatonin Act as an Antioxidant in Hydrogen Peroxide-Induced Oxidative Stress Model in Human Peripheral Blood Mononuclear Cells. Biochemistry Research InternationalVolume 2016 (2016), Article ID 5857940.P.8-15

EFSA, 2010. EFSA Panel on Dietetic Product, Nutrition and Allergic (NDA). EFSA Journal 2010; 8 (10): 1814: 1-28

Ehrlich, S. (August 6, 2015). Vitamin B3 (Niacin).Retrieved from https://umm.edu/health/medical/altmed/supplement/vitamin-b3-niacin

Wijayanti PD. 2012. Daya Hambat Ekstrak Stichorpus hermanii (Teripang Emas) Terhadap Pertumbuhan Jamur Candida albicans. Skripsi. FKG Universitas Hangtuah Surabaya

Sarhadizadeh N , Afkhami M,Ehsanpour M . 2014 . Evaluation bioactivity of a Sea cucumber, Stichopus hermanni from Persian Gulf . European Journal of Experimental Biology. 4(1): 258-254.

Pranoto, Eunike Noviana, Widodo Farid Ma’ruf, Delianis Pringgenies. Kajian Aktivitas Bioaktif Ekstrak Teripang Pasir (Holothuria Scabra) terhadap jamur Candida albicans. Jurnal Pengolahan dan Bioteknologi Hasil Perikanan. 2012: 1(1):8-1.

Laksono PA. Uji Antibakteri Fraksi Residu Ekstrak Etanol Buah Ceremai ( Phyllanthus acidus (L.) Skeels) Terhadap Staphylococcus aureus dan Escherichia coli Multiresisten Antibiotik [Skripsi]. Surakarta: Fakultas Farmasi Universitas Muhammadiyah; 2010. Available from http://etd.eprints.ums.ac.id/10106/1/K100060152.pdf.

Amaliah R. Munawir A, Dewi R. Efek Antifungal Ekstrak Etanol Siwak (Salvadora persica) terhadap pertumbuhan jamur Candida albicans pada Media Saboraud Dekstrose Agar. Jember: Fakultas Kedokteran Universitas Jember; 2013. h.7.

Kurniawan Christian J. Identifikasi komponen bioaktif bubuk teripang emas dan efektifitasnya terhadap jumlah koloni candida albicans pada tikus wistar yang mengalami oral candidiasis. Surabaya: Universitas Hang Tuah; 2016. h. 90-91

Tyastuti E, Sutarno, Kusmardi. Efek Imunostimulator Propolis terhadap Proliferasi Limfosit T dan Viabilitas Sel Tumor Mammae Mencit secara in Vitro. Bioteknologi. 2006; 3(1): 7-1.

Tsiodras S, Samonis G, Boumpas d, Kontoyiannis D. 2008. Fungal Infections Complicating Tumor Necrosis Factor Alpha Blockade Therapy. Mayo Clin Proc. p. 181-194

Arif Tasleem, Bhosale J.D, Kumar Naresh, Mandal T.K, Bendre R.S, Lavekar G.S, Dabur Rajesh, 2009. Natural Products-Antifungal Agents Derived From Plants. Journal of Natural Products Research Vol.11. No.7. July: 621-638

Lazuardi A, Ratrileondessy C, Widiyatuti D. 2007. Nutrisi untuk sistem Imun. Makalah Ajar. Jakarta.P.26-41

Meera S, V.S.S.S. Gupta Atyam and N.S. Kumar, 2008. Immunomodulatory and Antioxidant Activity of a Polyherbal Formulation. International Journal of Pharmacology.P.287-291

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Published

2021-08-16

How to Cite

Ajeng Hanun Winny Khairina, Syamsulina Revianti, & Nafi’ah. (2021). Effectivity of the Gold Sea Cucumber Supplementation (Stichopus hermanii) of Catalase Activity in Wistar Rat’s Submandibular with Oral Candidiasis . DENTA JURNAL KEDOKTERAN GIGI, 11(2), 38–47. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/93

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Vol. 11 No. 2 (2017): Agustus

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