Perbedaan Pengaruh Pemberian Kitosan Berat Molekul Tinggi dan Rendah terhadap Jumlah Pembuluh Darah pada Proses Penyembuhan Luka Pencabutan Gigi

Authors

  • Bella Sagita Puspita Sarjana Kedokteran Gigi Universitas Hang Tuah Surabaya
  • Sularsih IMTKG Fakultas Kedokteran Gigi Universitas Hang Tuah
  • Dian W. Damaiyanti Biologi Oral Fakultas Kedokteran Gigi Universitas Hang Tuah

Keywords:

Chitosan, molecular weight, angiogenesis, wound healing

Abstract

Background: Molecular weight is one of the chitosan characteristic that affects the effectiveness of application for wound healing in dental extraction. Chitosan could improve wound healing process because of its anti inflammation component and accelerate
proliferation phase. Angiogenesis is one of the main component in proliferation phase because it can preserve cells function to accelerate wound healing process. Purpose: the aim of this experiment is to account blood vessels in wound healing of dental extraction using chitosan with different molecular weight. Materials and Methods: Thirty six male Rattus Norvegicus were divided into 3 groups. Group I (without chitosan), group II was given low molecular weight chitosan, group III was given high molecular weight chitosan. Rats were sacrificed on day 7 and on day 14 post extraction then they were examined by hystometri to see the change in blood vessels number. Result: Data were statistically analyzed with One Way ANOVA and LSD with degree of significant p<0,05 showed significant difference between high molecular weight chitosan group and low molecular weight chitosan group after 7 and 14 days observation. Conclusion: High molecular weight chitosan was found more effective to increase blood vessels amount at 7th day and decrease blood vessels amount that 14 day in wound healing of dental extraction process.

Downloads

Download data is not yet available.

References

Frisca, Sardjono CT, Sandra F. 2009. Angiogenesis: Patofisiologi dan Aplikasi Klinis. JKM, 8(2): 187-174.

Morison MJ. 2004. Seri Pedoman Praktis. Manajemen Luka. Jakarta : EGC. P. 7-1.

Asparini RR. 2011. Peran Heparin dalam Angiogenesis, Epitelisasi dan Penyembuhan Luka Bakar. Jurnal Saintika Medika, 2011, 7(14): 31-26.

Miloro M. 2004. Peterson’s Principles of Oral and Maxillofacial Surgery 2nd edition. London: BC Decker Inc. P. 87.William TD, Vinchent W. 2003. Angiogenesis :A Control Point for Normal and Delayed Wound Healing. Suplement Contemporary Surgery:18-4.

Mitchell, Kumar, Abbas, Fausto. 2009. Dasar Patologis Penyakit Edisi 7. Andry Hartono (penerjemah), 2008. Jakarta:

EGC. H. 57. 6. Budihargono O, Yuliati A, dan Rianti D. 2013. Peningkatan Mobilisasi Sel Polimorfonuklear Setelah Pemberian Gel

Kitosan 1% pada Luka Pencabutan Gigi Cavia Cobaya. Material Dental Journal Universitas Airlangga. H. 1-6-1.

Ratnawati A, Djoni IR, Adri S. 2013. Sintesis dan Karakterisasi Kolagen dari Teripang-Kitosan sebagai Aplikasi Pembalut Luka. Available

from http://www.journal.unair.ac.id/filerPDF/jurnal%20AyuRatnawati.pdf. Diakses 26 Maret 2014.

Wiyarsi A, dan Priyambodo E. 2010. Pengaruh Konsentrasi Kitosan dari Cangkang Udang terhadap Efisiensi Penyerapan Logam Berat. Available from http://staff.uny.ac.id/sites/default/files/penelitian/Erfan%20Priyambodo,%20M.Si./kitosan.PDF. Diakses 4 April 2014.

Maeda Y, dan Kimura Y. 2004. Antitumor Effects of Various LowMolecular-Weight Chitosans Are Due to Increased Natural Killer Activity of

Intestinal Intraepithelial Lymphocytes in Sarcoma 180-Bearing Mice. J. Nutr. 134: 945-950.

Semalty A. 2006. Mucoadhesive Polymers – A Review. Available from http://www.pharmainfo.net/reviews/mucoadhesive-polymers-review. Diakses 6 Mei 2014.

Gunawan F. 2014. Perbedaan Pengaruh Kitosan Berat Molekul Rendah dan Tinggi terhadap Jumlah Sel Limfosit pada Proses Penyembuhan Luka Pencabutan Gigi. Skripsi. Universitas Hang Tuah, Surabaya. P. 18-17.

Sumardikan H. 2007. Penggunaan Carboxymethylcellulose (CMC) terhadap pH, Keasaman, Viskositas, Sineresis dan Mutu Organoleptik Yogurt Set. Skripsi. Universitas Brawijaya Malang. H. 1.

Siskawardani DD, Nur K, dan Moch. Bagus H. 2013. Pengaruh Konsentrasi Na-CMC (Sodium– Carboxymethyle Cellulose) dan Lama Sentrifugasi terhadap Sifat Fisik Kimia Minuman Asam Sari Tebu (Saccharum officinarum L). Jurnal Bioproses Komoditas Tropis,

(1).

Sularsih. 2011. Penggunaan Kitosan dalam Penyembuhan Luka Pencabutan Gigi Rattus norvegicus. Tesis. Universitas Airlangga Surabaya. H. 48-42.

Kung S, Devlin H, Fu E, Ho KY, Liang SY, Hsieh YD. 2011. The osteoconductive effect of kitosancholagen composites around pure titanium implant surface in rats. J Periodont Res 46:133-126.

Aranaz I, Mengíbar M, Harris R, Paños I, Miralles B, Acosta N, Galed G dan Heras Á. 2009. Functional Characterization of

Chitin and Chitosan. Current Chemical Biology, 3: 230-203.

Alsarra IA. 2009. Chitosan Topical Gel Formulation in the management of Burn Wounds. International Journal of Biological Macromolecules. P 21-16.

Inan ZDS, dan Serpil US. 2013. Investigation of the wound healing effects of chitosan on FGFR3 and VEGF

ımmunlocalization in experimentally diabetic rats. International Journal of Biomedical Materials Research, 1 (1): 81.

Kumar V, Cotran RS, Robbins, SL. 2004. Buku Ajar Patologi Edisi 7. Jakarta: EGC. P. 114-107.

Downloads

Published

2021-11-27

How to Cite

Bella Sagita Puspita, Sularsih, & Dian W. Damaiyanti. (2021). Perbedaan Pengaruh Pemberian Kitosan Berat Molekul Tinggi dan Rendah terhadap Jumlah Pembuluh Darah pada Proses Penyembuhan Luka Pencabutan Gigi . Denta: Jurnal Kedokteran Gigi, 9(2), 209–215. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/192

Issue

Vol. 9 No. 2 (2015): Agustus

Section

Articles

License

Copyright (c) 2021 Bella Sagita Puspita, Sularsih, Dian W. Damaiyanti

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.