The Effect of Hyperbaric Oxygen Therapy to the Amount of Lymphocytes in Oral Candidiasis Immunosuppressed Model

Authors

  • Agni Febrina Pargaputri Departemen Biologi Oral Fakultas Kedokteran Gigi Universitas Hang Tuah Surabaya
  • Dwi Andriani Departemen Biologi Oral Fakultas Kedokteran Gigi Universitas Hang Tuah Surabaya

Keywords:

Oral candidiasis, immunosuppressed, hyperbaric oxygen therapy, lymphocytes

Abstract

Background: Oral candidiasis generally caused by Candida albicans with prevalence of 30-50%. C. Albicans proliferation in the oral cavity was canducted by decreasing immune system of the host. Lymphocytes activation in immune system happened when there is a contact between host cell with cell wall of C. albicans as a result of C. albicans antigen. One of therapy to suppress the Candida infection sistemically is by giving hyperbaric oxygen therapy. Purpose: To determine the effects of giving hyperbaric oxygen therapy to the amount of lymphocytes in oral candidiasis immunosuppressed models. Methods: This research was post test only control group design. We used 12 wistar rats which were divided into 3 groups(n=4/3): K-(normal/ healthy wistar rats), K+(oral candidiasis immunosuppressed wistar rats), P1(oral candidiasis immunosuppressed wistar rats which were given hyperbaric oxygen therapy 5 days). K+ and P1 groups were immunosuppressed by giving dexamethasone 0,5mg/day/rat orally for 14 days, added with tetrasiklin 1 mg/day/rat. On the 3rd day immunosuppression, the rats were inducted with C.albicans smeared in the dorsum linguae once every two days for 12 days. Results: The data were analyzed with one way Anova test and showed significant difference among groups (p<0,05). To show the difference between each groups we used LSD test and showed significant difference (p<0,05) between K+ compared with P1, and K+ compared with K-. Conclusion: Hyperbaric oxygen therapy gives effect to the amount of lymphocytes in oral candidiasis immunosuppressed models.

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Published

2021-08-12

How to Cite

Agni Febrina Pargaputri, & Dwi Andriani. (2021). The Effect of Hyperbaric Oxygen Therapy to the Amount of Lymphocytes in Oral Candidiasis Immunosuppressed Model. DENTA JURNAL KEDOKTERAN GIGI, 12(2), 117–125. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/64

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Vol. 12 No. 2 (2018): Agustus

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Articles

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