Pengaruh Terapi Oksigen Hiperbarik Terhadap Jumlah Sel Osteosit pada Daerah Tekanan Saat Pergerakan Gigi Ortodonti

Authors

  • Ivan Nicholas Jonathan Sarjana Kedokteran Gigi Universitas Hang Tuah
  • Arya Brahmanta Ortodonsia Fakultas Kedokteran Gigi Universitas Hang Tuah
  • Pambudi Rahardjo Ortodonsia Fakultas Kedokteran Gigi Universitas Hang Tuah

Keywords:

Tooth movement, orthodontic force, osteocyte, nitric oxide, hyperbaric oxygen therapy (HBO)

Abstract

Backgrounds: Orthodontic tooth movement occurs as the result of mechanical force to teeth. Many cells are playing part to correspond the mechanical force, which one of them is osteocyte. Orthodontic force in pressure side induces osteocyte cell death. Hyperbaric oxygen therapy (HBOT) has many benefits, which one of them increases NO, of which can prevents osteocyte apoptosis. Purpose: To determine the influences of 3x30 minutes with 5 minutes break, 2,4 ATA HBOT for 5 and 7 days to osteocyte numbers on pressure side during orthodontic tooth movement. Materials and Methods: This study used “post test only control group” design, 42 guinea pigs were divided into 4 groups. K(-) was a negative control group, K(+) was the orthodontic group, and K1 & K2 were groups that given both orthodontic and HBOT for 5 and 7 days. Osteocyte numbers were counted after HE preparation. Data were analyzed by one way ANOVA and LSD test. Result: Data showed a significant difference of osteocyte amounts between K(-) group and K(+) group and between K(+) with K1 and K2 groups. Conclusions: HBOT for 5 days as well as 7 days gives a significant influences for the increase of osteocyte numbers on pressure side during tooth movement in Cavia cobaya.

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References

Al’amri M. 2012. Identifikasi Bakteri pada Pengguna Alat Ortodontik Cekat Mahasiswa FKG Universitas Hasanuddin. Skripsi. Universitas Hasanuddin. P. 12.

Alghamdi MYM. 2011. The Effects of Hyperbaric Oxygen Therapy on Bone Distant From Sites of Surgery. Thesis. University of Toronto. P. 36, 6, 1-2.

Ariffin SH, Yamamoto Z, Abidin IZZ, Wahab RMA, Ariffin ZZ. 2011. Cellular and Molecular Changes in Orthodontic Tooth Movement. The Scientific World Journal 11: 1803-1788.

Bonewald LF. 2011. The Amazing Osteocyte. J Bone Miner Res, 26(2): 22938.

Cooney, Norma L, Parks S. 2011. Pro Argument Avascular Necrosis HBO Indications List. P. 2. Available at

http://c.ymcdn.com/sites/membership.uhms.org/resource/resmgr/ne11_pdf/cooney.pdf. Diakses 12 Juni 2014.

Domenico MD, D’apuzzo F, Feola A,Cito L, Monsurro A, Pierantoni GM,Berrino L, De Rosa A, Polimeni A, dan Perillo L. 2012. Cytokines and VEGF Induction in OrthodonticMovement in Animal Models. Journal of Biomedicine and Biotechnology. P. 3.

Efrati S dan Gall N. 2009. Hyperbaric Oxygen, Oxidative Stress, NO Bioavailability and Ulcer Oxygenation in Diabetic Patients. The Institute of Hyperbaric Medicine and Wound Healing Tel-Aviv University Israel. UHM 2009,

: 8.

Elayan IM, Axley MJ, Prasad PV, Ahlers ST, dan Auker CR. 2000. Effect of Hyperbaric Oxygen Treatment on Nitric Oxide and Oxygen Free Radicals in Rat Brain. J. Neurophysiol, 83: 2022-9.

Heino TJ, Hentunen TA, Vaananen HK. 2002. Osteocytes Inhibit Osteoclastic Bone Resorption Through Transforming Growth Factor-beta: Enhancement by Estrogen. J Cell Biochem, 85(1): 185-97.Available from http://www.ncbi.nlm.nih.gov/pubmed/11891862. Diakses 7 Januari 2015.

Husin E, Tjandrawinata R, Juliani M,Roeslan BO. 2012. Orthodontic Force Application in Correlation with Salivary Lactate Dehydrogenase Activity. Journal of Dentistry Indonesia, 19(1): 13­10.

Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Eguchi T, Yoshida N. 2012. Inhibitory Effect of Interferon-γ on Experimental Tooth Movement in Mice. J Interferon Cytokine Res, 32(9): 426-31.

Kusumadewy W. 2012. Perbandingan Kadar Interleukin 1-0 Dalam Cairan Krevikular Gingiva Anterior Mandibula Pasien pada Tahap Awal Perawatan Ortodonti Menggunakan Braket SelfLigating Pasif dengan Braket Konvensional Pre-Adjust MBT. Thesis. Universitas Indonesia. H. 20, 13-5.

Lubis HS. 2012. Evaluasi Densitas Callus pada Tulang Panjang yang Dilakukan Internal Fiksasi menurut Gambaran Radiologis pada Minggu ke-12. Thesis.Universitas Sumatra Utara. H. 8.

Matsumoto T, Iimura T, Ogura K, Moriyama K, Yamaguchi A. 2013. The Role of Osteocytes in Bone Resorption during Orthodontic Tooth Movement. J Dent Res, 92(4): 345-340

Moin S, Kalajzic Z, Utreja A, Nihara J, Wadhwa S, Uribe F, Nanda R. 2014. Osteocyte Death during Orthodontic Tooth Movement in Mice. Angle Orthodontist. P. 1.

Niklas A, Proff P, Gosau M, Romer P. 2013. The Role of Hypoxia in Orthodontic Tooth Movement. International Journal of Dentistry. P. 7-1.

Nimeri G, Kau CH, Nadia SA, dan Corona R. 2013. Acceleration of Tooth Movement during Orthodontic Treatment-a Frontier in Orthodontics. Progress in Orthodontics Journal, 14(42):8-1.

Sanmuganathan D. 2011. The Role of Osteocyte in Orthodontic Tooth Movement in Rat Dento-alveolar Complex. Thesis. University of Adelaide.P. 28-9.

Scaffler MB dan Kennedy OD. 2012. Osteocyte Signalling in Bone. Curr Osteoporos Rep, 10(2): 125-118.

Sutomo S. 2012. The effect of Hyperbaric Oxygen in increasing the amount of Osteoblast cells on Remodeling process during tooth movement on male adult Cavia Cobaya. Orthodontic Dental Journal, 3(1) 2012: 32-22.

Takano T dan Yamamoto. 2013. Osteocyte Function Under Compressive Mechanical Force. Japanese Dental Science Review, 50: 39-29.

Tan SD. 2008. Osteocyte Apoptosis and Bone Adaptation. Thesis. Radboud University Nijmegen Medical Centre. P. 87-7.

Thom SR. 2009. Oxidative Stress in Fundamental of Hyperbaric Oxygen Therapy. Department of Emergency Medicine University of Pennsylvenia Medical Centre. J Appl Physiol, 3(106): 988-95.

Widowati W, Brahmanta A, Prameswari N. 2014. Pengaruh Terapi Oksigen Hiperbarik Terhadap Jumlah Osteosit Dari Marmut Jantan (Cavia cobaya). Skripsi. Universitas Hang Tuah. H. 3-1.

Xiong J & O’Brien CA. 2012. Osteocyte RANKL: New Insights into the Control of Bone Remodeling. Bone Miner Res, 27(3): 505-499.

Yamaguchi M. 2009. RANK⁄ RANKL OPG during Orthodontic Tooth Movement. Orthod Craniofac Res, 12: 113-9.

Devi A. 2012. Pengaruh Terapi Oksigen Hiperbarik Terhadap Peningkatan Ekspresi iNOS Pada Penyembuhan Luka. Thesis. Universitas Airlangga. H. 85.

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Published

2021-11-27

How to Cite

Ivan Nicholas Jonathan, Arya Brahmanta, & Pambudi Rahardjo. (2021). Pengaruh Terapi Oksigen Hiperbarik Terhadap Jumlah Sel Osteosit pada Daerah Tekanan Saat Pergerakan Gigi Ortodonti. DENTA JURNAL KEDOKTERAN GIGI, 9(2), 180–188. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/188

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Vol. 9 No. 2 (2015): Agustus

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Articles

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