Efektifitas Ekstrak Nannochloropsis oculata Terhadap Peningkatan Kepadatan Kolagen pada Proses Penyembuhan Alveolar Osteitis.

Authors

  • Ajeng Saghita Enggardini Sarjana Kedokteran Gigi Fakultas Kedokteran Gigi Universitas Hang Tuah
  • Syamsulina Revianti Biologi Mulut Fakultas Kedokteran Gigi Universitas Hang Tuah
  • Noengki Prameswari Biomedik Fakultas Kedokteran gigi Universitas Hang Tuah

Keywords:

Nannochloropsis oculata, collagen, alveolar osteitis

Abstract

Background: Alveolar osteitis was one complication after tooth extraction. This condition
remains a common post operative problem that results in severe pain and inhibit socket
healing. Nannochloropsis oculata’s extract contains alkaloids, carotenoids, flavonoids,
terpenoids and tocopherols that could accelerate the wound healing process. Purpose:
Examine the effectivity of Nannochloropsis oculata extract to the increased density of
collagen in alveolar osteitis healing process. Materials and Methods: This research design
was post-test only control group design, using 64 male Wistar rats then divided into two
major groups. Group 1 (irrigation) and group 2 (dressing). In each group contains a negative
control group (irrigation PBS or dressing PBS), positive control group (irrigation Saline
0,9% or dressing Alvogyl), and the treatment group (irrigation or dressing used
Nannochloropsis oculata extract 2,5% and 5%). After treatment on the 3rd and 7th day, rats
were euthanazied than collagen density was measured at histopathology slide used Masson’s
Trichom with magnification 100x under light microscope, than it what measured. Data was
analyzed with Kruskal-Wallis and Mann-Whitney test. Result: There were significant
differences of collagen density beetwen irrigation treatment groups (0,045), but there were
not significant differences beetwen dressing treatment groups (0,243). Dressing method was
more effective to increase collagen density than irrigation groups (0,026). Conclusion:
Dressing treatment used Nannochloropsis oculata extract concentration 5% was most
effective to increased the collagen density in alveolar osteitis healing process on 7th days.

 

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Published

2021-09-04

How to Cite

Ajeng Saghita Enggardini, Syamsulina Revianti, & Noengki Prameswari. (2021). Efektifitas Ekstrak Nannochloropsis oculata Terhadap Peningkatan Kepadatan Kolagen pada Proses Penyembuhan Alveolar Osteitis . DENTA JURNAL KEDOKTERAN GIGI, 10(1), 9–19. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/11

Issue

Vol. 10 No. 1 (2016): Februari

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