The Effectiveness of Golden Sea Cucumber Ethanol Extract on The Expression of Endoglin in The Maturation Phase of Healing Mice With Traumatic Ulcers

Authors

  • Rima Parwati Sari Department of Oral Biology, University of Hang Tuah Surabaya, Indonesia
  • Endah Wahjuningsih Department of Oral Biology, University of Hang Tuah Surabaya, Indonesia

Keywords:

Stichopus hermanii, ulcer healing, endoglin and traumatic ulcer.

Abstract

Background: The traumatic ulcer is the most common oral soft tissue lesion that cause physiologic dissorder (pain) in patients, so it need a medicine to improving healing processs.Stichopus hermanii contains glycosaminoglycans, omega-3 and other agents that accelerate wound healing. Their influence againts signaling cell for proliferation and angiogenic for healing procce. Endoglin plays in a number of cellu- lar processes and the elevated expression during wound healing. Purpose: Knowing the effectivity of ethanol extract of Stichopus hermanii towards the expression on traumatic ulcer maturation phase in oral mucosa. Materials and Methods: The research subjects were forty eight wistar rats divided into 6 groups. Traumatic ulcer was made in the center-rat’s-labial-mucosa. The X1 group was smeared with sterilized aquades as the control group. The X2  was smeared with 0,2% hialuronic acid,  X3 with 60% ethanol extract, and  X4 with 80% ethanol extract. They were smeared once a day during 4 days. On the sixth day, the rat’s labial mucosa was biopsied to make histological preparation in order to study the amount of fibroblast. Results: Kruskal-Wallis test showed not significant difference (p=0,000) after applying  Stichopus hermanii extract for expression of endoglin in Conclusions: ethanol extractStichpus hermanii not effective for expression of endoglin on  traumatic ulcer maturation phase in healing procces.

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Published

2021-08-26

How to Cite

Rima Parwati Sari, & Endah Wahjuningsih. (2021). The Effectiveness of Golden Sea Cucumber Ethanol Extract on The Expression of Endoglin in The Maturation Phase of Healing Mice With Traumatic Ulcers. DENTA JURNAL KEDOKTERAN GIGI, 11(1), 43–50. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/111

Issue

Vol. 11 No. 1 (2017): Februari

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