Pengaruh Kafein Terhadap Ekspresi RANKL dan Jumlah Osteoklas Pada Pergerakan Gigi Ortodonti

Authors

  • Herniyati Bagian Ortodonsia , Fakultas Kedokteran Gigi Universitas Jember

Abstract

Background: Orthodontic tooth movement depends on bone remodeling involving osteoclasts and osteoblasts. RANKL has an important role in osteoclastogenesis and increased during orthodontic tooth movement. Caffeine contained in coffee, tea, and carbonated drinks can increase osteoclastogenesis. Purpose: To analyze the effect of caffeine on the expression of RANKL  and  the  number  of  osteoclasts  in  orthodontic  tooth  movement.  Materials  and Methods: The experimental laboratories research used 16 rats  were divided into 2 groups: the control group (K): rats given orthodontic mechanical force (OMF) and the treatment group (P): rats given OMF and caffeine at 1,37mg / 100 g twice a day. OMF was conducted by ligature wires were applied on permanent maxillary right first molar and both permanent maxillary incisivus .Subsequently, the permanent maxillary right first molar  moved to mesial with  Ni-Ti  orthodontic  closed  coil  spring.  Observations  were  made  by  histological examination to calculate the number of osteoclasts and immunohistochemical examination to determine the expression of RANKL. Result: the administration of caffeine increased the number of osteoclast in both compression and tension areas (p<0.05). The number of osteoclast in compression area larger than those which in tension area (p<0.05), The administration  of caffeine  improved  the  expresion  of RANKL  in  both  compression    and tension areas (p<0.05). The expression of RANKL in compression area larger than those which in tension area (p<0.05), Conclusion:   The administration of caffeine increased the expression of RANKL and osteoclast numbers on orthodontic tooth movement, therefore it may be an alternative to accelerate orthodontic treatment.

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Published

2021-09-04

How to Cite

Herniyati. (2021). Pengaruh Kafein Terhadap Ekspresi RANKL dan Jumlah Osteoklas Pada Pergerakan Gigi Ortodonti. DENTA JURNAL KEDOKTERAN GIGI, 10(1), 62–70. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/20

Issue

Vol. 10 No. 1 (2016): Februari

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