Dentist Role in Increasing Quality of Life in Mucositis Patient with Acute Lymphoblastic Leukemia

Authors

  • Theodora Adhisty Dwiarie Residen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran, Bandung, Indonesia
  • Nanan Nur’aeny Department of Oral Medicine, Universitas Padjadjaran, Bandung, Indonesia
  • Nelly Nainggolan Oral Medicine Residency Program, Universitas Padjadjaran, Bandung, Indonesia

DOI:

https://doi.org/10.30649/denta.v16i1.2

Keywords:

Acute Lymphoblastic Leukemia, Chemotherapy, Mucositis, Quality of Life

Abstract

Background: Mucositis, a painful condition common in patients undergoing chemotherapy, can decrease the patient's quality of life. Treatment of mucositis by dentists supports the improvement of general health conditions and the patient's quality of life. This case report aims to discuss a case of a patient with mucositis after undergoing chemotherapy treatment for acute lymphoblastic leukemia. Case: 21 years old female diagnosed with acute lymphoblastic leukemia, referred to the oral medicine department from internal medicine, complained of pain in oral mucosa and lockjaw in the last three days after chemotherapy treatment with methotrexate. Internal medicine prescribes ceftriaxone intravenous (IV), dexamethasone IV, chlorhexidine gargle, and nystatin. Intraoral examination showed erosive lesions in the tongue, labial, and buccal mucosa and was diagnosed as oral mucositis grade 3 according to the World Health Organization scale. Her quality-of-life score is 46 according to The Functional Assessment of Cancer Therapy-General (FACT-G) and 58 according to Oropharyngeal Mucositis Quality of Life (OMQoL). Case management: She was treated with magic mouthwash containing diphenhydramine HCL, sucralfate, and aluminum hydroxide-magnesium hydroxide. Chlorhexidine and nystatin were advised to stop. The patient was instructed to keep her oral hygiene by gargling with sodium chloride and povidone-iodine after eating. Five days after the therapy, her condition improved (grade 1), and there was an increase in the FACT-G and OMQoL scores to 54 and 93. Conclusion: Mucositis can cause pain in the patient. A dentist can help diagnose and provide appropriate treatment to reduce the patient's complaints and improve the patient's quality of life.

Downloads

Download data is not yet available.

References

Terwilliger T, Abdul-Hay M. Acute lymphoblastic leukemia: a comprehensive review and 2017 update. Blood Cancer J 2017;7(6):e577.

Paul S, Kantarjian H, Jabbour EJ. Adult Acute Lymphoblastic Leukemia. Mayo Clin Proc 2016;91(11):1645–66.

Pavithran S, Sreeleksmi M V., Sreelekshmi R. Oral-health related quality of life of patients on chemotheray. Biomed Pharmacol J 2020;13(1):107–18.

Chaveli-López B, Bagán-Sebastián J V. Treatment of oral mucositis due to chemotherapy. J Clin Exp Dent 2016;8(2):e201–9.

Kirk LM, Brown SD, Luu Y, Ogle A, Huffman J, Lewis PO. Beyond-use dating of lidocaine alone and in two “magic mouthwash” preparations. Am J Heal Pharm 2017;74(9):e202–10.

Pulito C, Cristaudo A, Porta C La, Zapperi S, Blandino G, Morrone A, et al. Oral mucositis: The hidden side of cancer therapy. J Exp Clin Cancer Res 2020;39(1):1–15.

Kwon Y. Mechanism-based management for mucositis: Option for treating side effects without compromising the efficacy of cancer therapy. Onco Targets Ther 2016;9:2007–16.

Cidon EU. Chemotherapy induced oral mucositis: Prevention is possible. Chinese Clin Oncol 2018;7(1).

Poulopoulos A, Papadopoulos P, Andreadis D. Chemotherapy: oral side effects and dental interventions. A review of the literature. Stomatol Dis Sci 2017;1(2):35–49.

Curra M, Soares Junior LAV, Martins MD, Santos PS da S. Chemotherapy protocols and incidence of oral mucositis. An integrative review. Einstein (Sao Paulo) 2018;16(1):eRW4007.

Al-rudayni AHM, Gopinath D, Maharajan MK, Menon RK. Impact of oral mucositis on quality of life in patients undergoing oncological treatment : a systematic review. 2020;9(4):3126–34.

Hurrell L, Burgoyne L, Logan R, Revesz T, Gue S. The Management of Pediatric Oncology Inpatients with Oral Mucositis. J Pediatr Hematol Oncol 2019;41(8):E510–6.

Ahmad P, Akhtar U, Chaudhry A, Rashid U, Saif S, Asif JA. Treatment and prevention of oral mucositis: A literature review. Eur J Gen Dent 2019;8(2):23–8.

Damascena LCL, de Lucena NNN, Ribeiro ILA, Pereira TL, Lima-Filho LMA, Valença AMG. Severe oral mucositis in pediatric cancer patients: Survival analysis and predictive factors. Int J Environ Res Public Health 2020;17(4).

European Oral Care in Cancer Group Oral Care Guidance and Support First Edition.

Lee YH, Hong J, Kim I, Choi Y, Park HK. Prospective evaluation of clinical symptoms of chemotherapy-induced oral mucositis in adult patients with acute leukemia: A preliminary study. Clin Exp Dent Res 2020;6(1):90–9.

Scheibler E, da Silva RM, Leite CE, Campos MM, Figueiredo MA, Salum FG, et al. Stability and efficacy of combined nystatin and chlorhexidine against suspensions and biofilms of Candida albicans. Arch Oral Biol 2018;89(February):70–6.

Haydari M, Bardakci AG, Koldsland OC, Aass AM, Sandvik L, Preus HR. Comparing the effect of 0.06% -, 0.12% and 0.2% Chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: A parallel group, double masked randomized clinical trial. BMC Oral Health 2017;17(1):1–8.

James P, Worthington H V., Parnell C, Harding M, Lamont T, Cheung A, et al. Chlorhexidine mouthrinse as an adjunctive treatment for gingival health. Cochrane Database Syst Rev 2017;2017(3).

Brown TJ, Gupta A. Management of cancer therapy-associated oral mucositis. J Oncol Pract 2020;16(3):103–9.

Kusiak A, Alicjajereczek-Fossa B, Cichońska D, Alterio D. Oncological-therapy related oral mucositis as an interdisciplinary problem—literature review. Int J Environ Res Public Health 2020;17(7).

Gutiérrez-Vargas R, Díaz-García ML, Villasís-Keever MÁ, Portilla-Robertson J, Zapata-Tárres M. Instruments to measure the quality of life in patients with oral mucositis undergoing oncological treatment: a systematic review of the literature. Boletín Médico Del Hosp Infant México (English Ed 2016;73(6):457–66.

Berger K, Schopohl D, Bollig A, Strobach D, Rieger C, Rublee D, et al. Burden of Oral Mucositis: A Systematic Review and Implications for Future Research. Oncol Res Treat 2018;41(6):399–405.

Al Barmawi M, Al Hadid L, Alqudah H, Al Hadid W, Shamoun S. Measuring the Quality of Life among Head-and/or-Neck Cancer Patients with Oral Mucositis Using the Functional Assessment of Cancer Therapy-General in Jordan. Asia-Pacific J Oncol Nurs 2018;5(3):320–6.

Nunez-Aguilar J, Oliveros-Lopez LG, Fernandez-Olavarria A, Torres-Lagares D, Serrera-Figallo MA, Gutierrez-Corrales A, et al. Influence of dental treatment in place on quality of life in oral cancer patients undergoing chemoradiotherapy. Med Oral Patol Oral Cir Bucal 2018;23(4):e498–505.

Jung Y-S, Park E-Y, Sohn H-O. Oral Health Status and Oral Health-related Quality of Life According to Presence or Absence of Mucositis in Head and Neck Cancer Patients. J Cancer Prev 2019;24(1):43–7.

Zimmermann C, Meurer MI, Grando LJ, Gonzaga Del Moral JÂ, Da Silva Rath IB, Schaefer Tavares S. Dental Treatment in Patients with Leukemia. J Oncol 2015;2015:1–14.

Kochhar AS, Bhasin R, Kochhar GK, Dadlani H. Provision of continuous dental care for oral oncology patients during & after COVID-19 pandemic. Oral Oncol 2020;106(January).

Downloads

Published

2022-02-28

How to Cite

Theodora Adhisty Dwiarie, Nanan Nur’aeny, & Nelly Nainggolan. (2022). Dentist Role in Increasing Quality of Life in Mucositis Patient with Acute Lymphoblastic Leukemia. DENTA JURNAL KEDOKTERAN GIGI, 16(1), 6–12. https://doi.org/10.30649/denta.v16i1.2

Issue

Section

Articles

Most read articles by the same author(s)