Role of C-type Lectin Receptor to C.albicans on Promotion of Inflamantory Diseases

Authors

  • Erna Sulistyani Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi Universitas Jember

Keywords:

C. albicans, CLR, Cytokine, Inflamatory Disease

Abstract

In early 2010 there was a very rapid progress in the development of immunity to fungi, i.e  the discovery of CLR. CLR is one of the PRR receptors found in immune cells that recognize the cell wall of fungi and then trigger a transduction signal that eventually provoke the production of various proinflamatory include IL1β, IL6, TNF α and induce polarization  Th17.  In the condition of infection the number of innate immune cells increases dramatically, lead to increasing of cytokines produced. Both cytokines and the cells that produce them enter the bloodstream. If there is unbalance level of pro and anti inflammatory cytokine, various inflammatory and/or autoimmune diseases can be occur. Unlike the focal concept infection, where the agent will cause disease if  enters the blood vessels, through this concept a fungal infection at epithelium can lead to inflammatory  diseases in other part of body without having to go through fungus

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Published

2021-08-16

How to Cite

Erna Sulistyani. (2021). Role of C-type Lectin Receptor to C.albicans on Promotion of Inflamantory Diseases. DENTA JURNAL KEDOKTERAN GIGI, 11(2), 63–72. Retrieved from https://journal-denta.hangtuah.ac.id/index.php/jurnal/article/view/98

Issue

Vol. 11 No. 2 (2017): Agustus

Section

Articles

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