Beneficial Effect of Arabica Coffee Fruit Skin (Coffea Arabica) on Epithelial Thickness after Tooth Extraction


  • Fadhila Zidni Ilma Undergraduate Student, Faculty of Dentistry, Jember University
  • Tecky Indriana Department of Biomedical, Faculty of Dentistry, Jember University
  • Agus Sumono Department of Dental Material, Faculty of Dentistry, Jember University



Tooth extraction, epithelial thickness, arabica coffee fruit skin


Background: In Indonesia, tooth extraction is the most common practice in dentistry. A successful indicator of tooth extraction is a perfect healing process. One of the parameters of a perfect healing process is epithelial formation. Based on previous research, arabica coffee fruit skin has proven potential to accelerate the wound healing process. The compounds in the arabica coffee fruit skin are mostly composed of flavonoids, tannins, and chlorogenic acid. Purpose: This research is proposed to understand the beneficial effect of arabica coffee fruit skin (Coffea arabica) towards the increase of epithelial thickness in post tooth extraction socket. Material and Method: The type of this research was laboratory experimental in vivo with post-test only control group design using 24 Wistar rats as a sample. The sample was separated into two groups, control and intervention groups with 12 Wistar rats each. Treatment in both groups was given during 3, 5, and 7 days. Afterward, tissue processing undergoes with buccolingual cutting and HE coloring. Measurements are carried out with the ImageRaster software in the thickest and thinnest part of the epithelium that covers the tooth socket. Result: Epithelial thickness after tooth extraction increased significantly (p<0.05) in the intervention group compared to the control group. Conclusion: Arabica coffee fruit skin has the beneficial effect of increasing the epithelial thickness after tooth extraction.


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Kemenkes RI. Laporan Nasional RISKESDAS 2018. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2019.

Tamara AHJ, Rochmah YS, Mujayanto R. Pengaruh aplikasi virgin coconut oil terhadap peningkatan jumlah fibroblas pada luka pasca pencabutan gigi pada Rattus novergicus. Odonto Dent J. 2014; 1(2): 29-34.

Tarakji B, Saleh LA, Umair A, Azzeghaiby SN, dan Hanouneh S. Systemic review of dry socket: aetiology, treatment, and prevention. J Clin Diag Res. 2015; 9(4): 10-3.

Abu Younis MH, Abu Hantash RO. Dry socket: frequency, clinical picture, and risk factors in a Palestinian dental teaching center. Open Dent J. 2011; 5: 7-12.

A. Ten Cate’s Oral Histology, Development, Structure and Function. 9th ed. St. Louis: Mosby Elsevier; 2018. p. 320-4.

Throne CH. Grabb and Smith's Plastic Surgery. 7th ed. Philadelphia: Lippincott Williams & Willkins; 2014.p. 14-7.

Apriasari ML, Endariantari A, Oktaviyanti IK. The effect of 25% mauli bananan stem extract gel to increase the epithel thickness of wound healing process in oral mucosa. Dental Journal. 2015; 48(3): 150-3.

Pastar I, Stojadinovic O, Yin NC, Ramirez H, Nusbaum AG, Sawaya A, Patel SB, Khalid L, Isseroff RR, Tomic-canic M. Epithelization in wound healing: a comprehensive review. Adv Wound Care. 2014; 3(7): 445-64.

Hussaana A, Sarosa H, Indrayani UD, Chodidjah C, Widiyanto B, Pertiwi D. Formula jamu antihipertensi and captopril are equally effective in patients with hypertension. Univ Medi. 2016; 35(2): 81-8.

Torres-Valenzuela LS, Serna-Jiménez JA, Martinez K. Coffee by-products: nowadays and perspectives. Spain: In Tech Open; 2019. p.1-18.

Masruri A, Sumono A, Indriana T. 2019. Arabica coffee (Coffea arabica) fruit skin potential towards the increase of fibroblast cells amount within socket post tooth extraction of male wistar mouse. Health Notions. 2019; 3(6): 273-8.

Esquivel P, Jiménez VM. Functional properties of coffee and coffee by-product. J Food Res. 2011; 46(2): 488-95.

Ameca GM, Cerrilla MEO, Córdoba PZ, Cruz AD, Hernández MS, Haro JH. Chemical composition and antioxidant capacity of coffee pulp. Ciência e Agrotecnologia. 2018; 42(3): 307-13.

Al-Asmari KM, Abu Zeid IM, Al-Attar AM. Medicinal properties of Arabica coffee (Coffea arabica) oil: An Overview. Adv In Life Sci (ALS) Int J. 2020; 8(1): 20-29.

Ningsih JR, Haniastuti T, Handajani J. Re-epitelisasi luka soket pasca pencabutan gigi setelah pemberian gel getah pisang raja (Musa sapientum L) kajian histologis pada marmut (Cavia cobaya). JKGI. 2019; 2(1): 1-6.

Rupina W, Trianto HF, Fitrianingrum I. Efek salep ekstrak etanol 70% daun karamunting terhadap re-epitelisasi luka insisi kulit tikus wistar. eJKI. 2016; 4(1): 26-30.

Smith N. A Comparative Histological and Radiographic Study of Extraction Socket Healing in the Rat. Aust Dent J. 1974; 19(4): 250-4.

Agarwal PK, Singh A, Gaurav K, Goel S, Khanna HD, Goel RK. Evaluation of wound healing activity of extracts of plantain banana (M. sapientum var. parasidiaca) in rats. Indian J Exp Biol. 2009; 47(1): 322-40.

Thakur R, Jain N, Pathak R, Shandu SS. Practice in wound healing studies of plants. Evid Based Complement Alternat Med. 2011; 26: 1-15.

Li K, Diaho Y, Zhang H, Wang S, Zhang Z, Yu B. Tanin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound helaing in rats. BMC Complement Altern Med. 2011; 11: 86.

Rahayu YC, Yuwono B, Wandasari A. The effectiveness of proanthocyanidins cacao pods (Theobroma cacao l) on increasing socket epithelial thickness post toothextraction in wistar rats. J Dentomaxillofac Sci. 2020; 5(1): 12-6.

Perdani CG, Pranowo D, Qonitatilah. Total phenols content of green coffee (Coffea arabica and Coffea canephora) in East Java. IOP Conf Ser: Earth Environ Sci 230. 2019: 1-5.

Duangjai A, Suphrom N, Wungrath J, Ontawong A, Nuengchamnong N, Yosboonruang A. Comparison of antioxidant, antimicrobial activity and chemical profiles of three coffee (Coffea arabica L.) pulp aqueous extracts. Integr Med Res. 2016; 5(4): 324-31.




How to Cite

Fadhila Zidni Ilma, Tecky Indriana, & Agus Sumono. (2021). Beneficial Effect of Arabica Coffee Fruit Skin (Coffea Arabica) on Epithelial Thickness after Tooth Extraction. DENTA, 15(1), 17–23.